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82944-14-7

Benzoyl chloride, 2-hydroxy-3-methoxy- (9CI) synthesis

2synthesis methods
-

Yield:-

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane; for 1 h;Heating / reflux;

Steps:

56.1 2-Hydroxy-3-methoxy-benzoyl Chloride

5 g of 3-methoxy-salicylic acid were suspended in 40 ml dichloromethane and 10 ml of thionyl chloride and 0.5 ml of DMF were added. The mixture was refluxed for 1 hour and the solvent evaporated, the temperature being maintained below 40° C., to give 5 g of a white solid which was used as such in the following step

References:

US2005/124664,2005,A1 Location in patent:Page/Page column 33