BENZOYL CHLORIDE, 3-CHLORO-4-HYDROXY synthesis
- Product Name:BENZOYL CHLORIDE, 3-CHLORO-4-HYDROXY
- CAS Number:59595-94-7
- Molecular formula:C7H4Cl2O2
- Molecular Weight:191.01
3964-58-7
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Yield:59595-94-7 100%
Reaction Conditions:
with oxalyl dichloride in dichloromethane;N,N-dimethyl-formamide at 20; for 2 h;
Steps:
46.B Step B: 3-Chloro-4-hydroxybenzoyl chloride:
To a suspension of the product of Step A (0.61 g; 3.53 mmol) in anhydrous CH2CI2 (15 ml) oxalyl chloride (0.45 ml; 5.32 mmol) was added at room temperature with stirring, followed by anhydrous DMF (0.1 ml). This was stirred for 2 h at room temperature and solvents were removed under reduced pressure. The residue was kept in vacuo for 1 h to give the title compound (0.68g; 100%), as creamy solid, which was used in next step without further purification.
References:
WO2014/63199,2014,A1 Location in patent:Page/Page column 76
99-96-7
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