ChemicalBook CAS DataBase List BENZYL 2-BROMOETHYLCARBAMATE

BENZYL 2-BROMOETHYLCARBAMATE synthesis

7synthesis methods

Product Name:BENZYL 2-BROMOETHYLCARBAMATE
CAS Number:53844-02-3
Molecular formula:C10H12BrNO2
Molecular Weight:258.11

2576-47-8 Synthesis

2576-47-8
469 suppliers
$8.00/25g

501-53-1
393 suppliers
$10.00/1g

53844-02-3
84 suppliers
$5.00/250mg

Yield:53844-02-3 99%

Reaction Conditions:

with sodium hydroxide in 1,4-dioxane;water at 0 - 20; for 13.33 h;Inert atmosphere;

Steps:

B.3
A cooled (0° C.) mixture of 2-bromoethylamine hydrobromide (12.000 g ; 58.56 mmol ; 1.0 eq.) in dioxane (60 ml) was treated with aq. 1M NaOH (117.2 ml ; 117.20 mmol ; 2.0 eq.), and dropwise (over 10 min.) with benzyl chloroformate (8.4 ml ; 58.8 mmol ; 1.0 eq.). The resulting mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 13 h. Et₂O (300 ml) was added, and the colorless organic layer was further washed with water (75 ml), dried over anh. MgSO₄, filtered, and finally concentrated to dryness under reduced pressure to afford (2-bromo-ethyl)-carbamic acid benzyl ester as a colorless oil which was further dried under HV (15.020 g ; 99%). LC-MS: t_R=0.95 min. ; [M+H]⁺: no ionisation.

References:

Aissaoui, Hamed;Boss, Christoph;Koberstein, Ralf;Siegrist, Romain;Sifferlen, Thierry US2011/105514, 2011, A1 Location in patent:Page/Page column 21

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