benzyl 3-(methylamino)propylcarbamate synthesis
1synthesis methods
- Product Name:benzyl 3-(methylamino)propylcarbamate
- CAS Number:543745-14-8
- Molecular formula:C12H18N2O2
- Molecular Weight:222.28
Yield:-
Reaction Conditions:
in dichloromethane;
Steps:
47.A Part A.
Part A. Preparation of benzyl 3-(methylamino)propylcarbamate To benzyl chloroformate (1 g, 5.8 mmol) in CH2Cl2 (25 mL) at 0° C. was added dropwise imidazole (0.79 g, 11.7 mmol) in CH2Cl2 (20 mL). After the additon was complete the reaction was stirred at room temperature for 15 min., then washed with 10% citric acid, brine, and dried (MgSO4). The product obtained was combined with N-methyl-1,3-propane diamine (0.6 mL, 5.8 mmol) and DMAP (15 mg) in CH2Cl2 (30 mL) and stirred for 24 h.
References:
US2003/212054,2003,A1