BENZYL (4-BROMOBUTYL)CARBAMATE synthesis

5synthesis methods

Product Name:BENZYL (4-BROMOBUTYL)CARBAMATE
CAS Number:101625-10-9
Molecular formula:C12H16BrNO2
Molecular Weight:286.16

558-13-4 Synthesis

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Yield:101625-10-9 99.5%

Reaction Conditions:

with triphenylphosphine in dichloromethane;

Steps:

22.b 6-Amino-2-((2-methyl-1-(3-phenylpropanoylamino)propyl)hydroxyphosphinoyl)methylhexanoic acid

(b) The 4-benzyloxycarbonylamino-1-butanol (8.15 g) obtained in the above step (a) and carbon tetrabromide (15.12 g) were dissolved in methylene chloride (130.4 ml) and cooled with water. The mixture was added with triphenylphosphine (14.4 g) and returned to room temperature, and then stirred for 4 hours. The reaction system was concentrated under reduced pressure without any treatment, and the residue was purified by silica gel column chromatography (400 g, hexane:ethyl acetate=5:2) to obtain 1-benzyloxycarbonylamino-4-bromobutane (10.4 g, 99.5%). ¹H-NMR(CDCl₃): δ1.58-1.72(2H,m), 1.84-1.94(2H,m), 3.18-3.28(2H,dd), 3.42(2H,dd), 4.80(1H,s), 5.10(2H,s), 7.29-7.39(5H,m). EIMS(m/z): 286(M⁺).

References:

US6576627,2003,B1

17996-13-3
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$23.00/250mg

101625-10-9
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References

24566-81-2 Synthesis