ChemicalBook CAS DataBase List BENZYL METHYL MALONATE

BENZYL METHYL MALONATE synthesis

9synthesis methods

Product Name:BENZYL METHYL MALONATE
CAS Number:52267-39-7
Molecular formula:C11H12O4
Molecular Weight:208.21

67-56-1 Synthesis

67-56-1
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Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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52267-39-7
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Yield: 94%

Reaction Conditions:

with 1,4-diaza-bicyclo[2.2.2]octane;palladium diacetate in water;acetonitrile at 20; for 0.0833333 h;

Steps:

6 Example 6
To a 25 mL reaction flask equipped with a magnetic stirrer, 57.2 mg (0.2 mmol) of the 3-iodopropynyl compound represented by Formula 1-B, 12.8 mg (0.4 mmol) of methanol, and 7.2 mg (0.4 mmol) of water were successively added. ),Pd(OAc) 2, 0.45 mg (1 mol %), DABCO 44.8 mg (0.4 mmol), and then 2 mL of acetonitrile as a reaction solvent,The reaction was stirred at room temperature under air atmosphere for 5 minutes, and the reaction was confirmed by GC or TLC analysis.After the reaction, the mixture was washed with saturated Na2S2O3, extracted with ether and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure.The residue was separated by column chromatography on silica gel (n-hexane/ethyl acetate as eluent) to give the target product 3-F as a colorless liquid, yield 94%.

References:

Hunan First Normal University;Tang Jiansheng CN107954872, 2018, A Location in patent:Paragraph 0045-0047