![](/CAS/GIF/1020-16-2.gif)
BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE synthesis
- Product Name:BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE
- CAS Number:1020-16-2
- Molecular formula:C13H18ClNO2
- Molecular Weight:255.74
![Morpholine](/CAS/GIF/110-91-8.gif)
110-91-8
677 suppliers
$9.00/1g
![Formaldehyde](/CAS/GIF/50-00-0.gif)
50-00-0
847 suppliers
$10.00/25g
![Acetophenone](/CAS/GIF/98-86-2.gif)
98-86-2
742 suppliers
$9.00/5g
![BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE](/CAS/GIF/1020-16-2.gif)
1020-16-2
26 suppliers
$22.19/5g
Yield: 75%
Reaction Conditions:
with hydrogenchlorideReflux;Mannich Aminomethylation;
Steps:
3.1. General procedure for synthesis of Mannich bases
General procedure: Mannich bases were synthesized according to the given literature procedure. 23 A mixture of paraformaldehyde(1.80 g, 1.2 eq., 60.0 mmol), ketone (1.0 eq., 50.0 mmol), morpholine (4.35 g, 1.0 eq., 50.0 mmol), andhydrochloric acid (1.0 eq., 50.0 mmol) in ethanol was stirred at refl ux. The reaction was monitored by TLC.After the completion of the reaction, crude product was fi ltered and recrystallized in ethanol.3-Morpholino-1-phenylpropan-1-one hydrochloride (1a): White solid; mp 177-178 °C (lit. 175-178 °C); yield: 75%. 24
References:
Seyi̇Tdanlioğlu, Pınar;Hanashalshahaby, Essam Hamied Ahmed;Ünaleroğlu, Canan [Turkish Journal of Chemistry,2018,vol. 42,# 6,p. 1598 - 1610]
![Formaldehyde](/CAS/GIF/50-00-0.gif)
50-00-0
847 suppliers
$10.00/25g
![MORPHOLINIUM CHLORIDE](/CAS/GIF/10024-89-2.gif)
10024-89-2
120 suppliers
$5.00/5g
![Acetophenone](/CAS/GIF/98-86-2.gif)
98-86-2
742 suppliers
$9.00/5g
![BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE](/CAS/GIF/1020-16-2.gif)
1020-16-2
26 suppliers
$22.19/5g
![Bromobenzene](/CAS/GIF/108-86-1.gif)
108-86-1
497 suppliers
$10.00/5g
![BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE](/CAS/GIF/1020-16-2.gif)
1020-16-2
26 suppliers
$22.19/5g
![1,3,5-trioxane](/CAS/GIF/110-88-3.gif)
110-88-3
228 suppliers
$10.00/25g
![MORPHOLINIUM CHLORIDE](/CAS/GIF/10024-89-2.gif)
10024-89-2
120 suppliers
$5.00/5g
![Acetophenone](/CAS/GIF/98-86-2.gif)
98-86-2
742 suppliers
$9.00/5g
![BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE](/CAS/GIF/1020-16-2.gif)
1020-16-2
26 suppliers
$22.19/5g