ChemicalBook CAS DataBase List BINDONE

BINDONE synthesis

12synthesis methods

Product Name:BINDONE
CAS Number:1707-95-5
Molecular formula:C18H10O3
Molecular Weight:274.27

1003-29-8
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606-23-5
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1707-95-5
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$34.00/1g

Yield: 89%

Reaction Conditions:

with pyridine in ethanolReflux;Knoevenagel Condensation;

Steps:

Synthesis of 2-((1H-pyrrol-2-yl)methylene)-1H-indene-1,3(2H)-dione (PP6)
Indane-1,3-dione (6.50 g, 44.47 mmol, M = 146.14 g/mol) and 1H-pyrrole-2-carbaldehyde (4.22 g, 44.47mmol, M = 95.10 g/mol) were dissolved in ethanol (50 mL) and a few drops of pyridine were added.The solution was heated at reflux overnight, providing a precipitate. After cooling, it was filtered off,washed several times with ethanol and pentane, and dried under vacuum. The reaction product wasidentified as bindone, the product resulting from the self-condensation of indane-1,3-dione (5.43 g,89% yield, grey solid).

References:

Bonardi, Aude-Héloise;Dumur, Frédéric;Duval, Sylvain;Gigmes, Didier;Lalevée, Jacques;Noirbent, Guillaume;Xu, Yangyang [Molecules,2020,vol. 25,# 10] Location in patent:supporting information

606-23-5
267 suppliers
$5.00/1g

1707-95-5
74 suppliers
$34.00/1g

References

606-23-5
267 suppliers
$5.00/1g

352-34-1 Synthesis