ChemicalBook CAS DataBase List Biotin-PEG6-NH-Boc

Biotin-PEG6-NH-Boc synthesis

11synthesis methods

Product Name:Biotin-PEG6-NH-Boc
CAS Number:1292268-20-2
Molecular formula:C29H54N4O10S
Molecular Weight:650.82

5,8,11-Trioxa-12-thia-2-azatridecanoic acid, 1,1-dimethylethyl ester, 12,12-dioxide

430430-57-2
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1292268-20-2
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Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: sodium hydroxide / water; toluene / 1 h / 100 °C
1.2: 20 - 100 °C
2.1: triethylamine / dichloromethane / 0.08 h / 0 °C
2.2: 24 h / 0 - 20 °C
3.1: sodium azide; sodium iodide / water; acetone / 48 h / 80 °C
4.1: palladium 10% on activated carbon; potassium chloride; hydrogen / ethanol / 760.05 Torr
5.1: N,N-dimethyl-formamide / 20 °C

References:

Moreau, Julie;Marchand-Brynaert, Jacqueline [European Journal of Organic Chemistry,2011,# 9,p. 1641 - 1644]