ChemicalBook CAS DataBase List bis(3',5')-cyclic diguanylic acid

bis(3',5')-cyclic diguanylic acid synthesis

2synthesis methods

Product Name:bis(3',5')-cyclic diguanylic acid
CAS Number:61093-23-0
Molecular formula:C20H24N10O14P2
Molecular Weight:690.41

81279-39-2 Synthesis

N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu

81279-39-2
95 suppliers
$27.00/250mg

61093-23-0
72 suppliers
$131.00/500ug

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: 100 percent / pyridinium trifluoroacetate / nitromethane / 1 h / 20 °C
2.1: pyridinium trifluoroacetate / acetonitrile / 0.5 h / 20 °C
2.2: 89 percent / tert-butylhydroperoxide / acetonitrile / 0.5 h / 20 °C
3.1: 91 percent / Amberlite IR-120 sulfonic acid resin / methanol / 0.25 h
4.1: adamantoylcarbonyl chloride / pyridine / 0.03 h / 20 °C
4.2: 80 percent / N-bromosuccinimide / pyridine / 0.25 h / 20 °C
5.1: 79 percent / aq. NH₃ / pyridine / 48 h

References:

Zhang, Zhaoying;Gaffney, Barbara L.;Jones, Roger A. [Journal of the American Chemical Society,2004,vol. 126,# 51,p. 16700 - 16701]

Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite] (9CI)

118684-41-6
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61093-23-0
72 suppliers
$131.00/500ug

References