ChemicalBook CAS DataBase List BIS(4-TRIFLUOROMETHYLPHENYL)CHLOROPHOSPHINE

BIS(4-TRIFLUOROMETHYLPHENYL)CHLOROPHOSPHINE synthesis

5synthesis methods

Product Name:BIS(4-TRIFLUOROMETHYLPHENYL)CHLOROPHOSPHINE
CAS Number:13685-24-0
Molecular formula:C14H8ClF6P
Molecular Weight:356.63

bis(4-(trifluoroMethyl)phenyl)phosphine oxide

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BIS(4-TRIFLUOROMETHYLPHENYL)CHLOROPHOSPHINE

13685-24-0
32 suppliers
$85.09/1g

Yield: 96%

Reaction Conditions:

with acetyl chloride in tetrahydrofuran at 25;Inert atmosphere;

Steps:

2.1 General procedure A for the synthesis of chlorophosphines 2a to 2e
General procedure: To an 10mL oven-dried Schlenk tube under argon atmosphere were added R₁R₂P(O)H (1.0 mmol) and THF (2.0 mL), stirring the solution until all the solid was totally dissolved, and then MeC(O)Cl (2.0 mmol) was added to the solution and the mixture was stirred at room temperature or 50^oC for overnight. After reaction, the excessive MeC(O)Cl, byproduct AcOH and solvent THF were removed under vacuum to afford pure R¹R²PCl.

References:

Zhang, Jian-Qiu;Yang, Shangdong;Han, Li-Biao [Tetrahedron Letters,2020,vol. 61,# 10,art. no. 151556] Location in patent:supporting information