Bispyribac synthesis

Yield:125401-75-4 85%

Reaction Conditions:

with tetrabutylammomium bromide;potassium carbonate in tolueneReflux;Reagent/catalyst;Solvent;

Steps:

1
0.04 mol of 2,6-dihydroxybenzoic acid was weighed separately,0.05 mol of 2-methanesulfonyl-4,6-dimethoxypyrimidine,0.004 mol of tetrabutylammonium bromide,0.08 mol of potassium carbonate was placed in a reaction vessel,Add 300mL toluene heated reflux reaction 8 ~ 1 Oh,The reaction is cooled and filtered,The filter cake was washed with toluene,dry,The resulting solid was mixed with 500 mL of water,Stir,Dropping 30% HC1 to the system PH = 3 ~ 4,filter,dry,Was gray and solidbodyBispyribac15.7g,Purity 97%Yield 85%.

References:

Zibo Xinnong Jinongyao Chemical Co.,Ltd;ZHENG, YOUKUI;SONG, JUN;WANG, XIAOWEI CN106083738, 2016, A Location in patent:Paragraph 0019; 0020

FullText