ChemicalBook CAS DataBase List Bixafen|

Bixafen| synthesis

8synthesis methods

Product Name:Bixafen|
CAS Number:581809-46-3
Molecular formula:C18H12Cl2F3N3O
Molecular Weight:414.21

1H-Pyrazole-4-carbonyl chloride, 3-(difluoromethyl)-1-methyl-

141573-96-8
6 suppliers
inquiry

877179-04-9
51 suppliers
$228.00/250mg

581809-46-3
61 suppliers
$100.00/50mg

Yield:581809-46-3 99%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in toluene at 60; for 4 h;Temperature;Reagent/catalyst;Solvent;

Steps:

1.3; 2.3; 3.3 Step 3

Dissolve (48.65 g, 0.19 mol) of the intermediate 3',4'-dichloro-5-fluoro-2-benzidine in 500 ml of solvent toluene, and add the catalyst N,N-diisopropylethylamine. (24.55 g, 0.19 mol), 1-methyl-3-difluoromethyl-4-pyrazolecarbonyl chloride (36.96 g, 0.19 mol) was added with stirring at 60 ° C, and reacted at 60 ° C for 4 h, cooled after reaction. The reaction liquid was washed with water at room temperature, and the organic phase was separated, dried, concentrated by rotary evaporation, and recrystallized to give 77.91 g of the above-mentioned bixafen, yield: 99%.

References:

CN110117256,2019,A Location in patent:Paragraph 0023; 0027; 0028; 0032; 0033