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BN 80245 synthesis

6synthesis methods
Indolizino[1,2-b]quinolin-9(11H)-one, 8-[(formyloxy)methyl]-7-(1-oxopropyl)-

54318-62-6
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BN 80245

186668-40-6
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-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1.) Zn, TMSCl / 1.) Et2O, reflux, 1 h, 2.) THF, reflux, 1 h
2: 55 percent / HCl / CH2Cl2 / 16 h / -20 °C

References:

Lavergne, Olivier;Lesueur-Ginot, Laurence;Rodas, Francesc Pla;Kasprzyk, Philip G.;Pommier, Jacques;Demarquay, Danièle;Prévost, Grégoire;Ulibarri, Gérard;Rolland, Alain;Schiano-Liberatore, Anne-Marie;Harnett, Jeremiah;Pons, Dominique;Camara, José;Bigg, Dennis C. H. [Journal of Medicinal Chemistry,1998,vol. 41,# 27,p. 5410 - 5419]