BOC-D-HOMOSER-OBZL synthesis
- Product Name:BOC-D-HOMOSER-OBZL
- CAS Number:133645-53-1
- Molecular formula:C16H23NO5
- Molecular Weight:309.36
![D-Homoserine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI)](/CAS/GIF/745011-75-0.gif)
745011-75-0
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Yield:133645-53-1 91%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide;
Steps:
20.1 Step 1. Benzyl (tert-butoxycarbonyl)-D-homoserinate.
A mixture of Boc (D)-homoserine (1.0 g, 4.3 mmol), benzyl bromide (1.1 g, 6.5 mmol) and potassium carbonate (0.8 g, 8.7 mmol) in DMF (5 mL) was stirred overnight. The reaction mixture was diluted with water and extracted with IPAC/heptane mixture. The organic layer was washed with brine, dried over sodium sulfate and concentrated. The residue was purified by flash chromatography (silica gel, 0-100% IPAC/heptane) to obtain 1.2 g (91%) of the title compound.
References:
WO2020/185999,2020,A1 Location in patent:Paragraph 00283
92828-64-3
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24424-99-5
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