ChemicalBook CAS DataBase List BOC-ILE-GLY-OH

BOC-ILE-GLY-OH synthesis

4synthesis methods

Product Name:BOC-ILE-GLY-OH
CAS Number:16257-05-9
Molecular formula:C13H24N2O5
Molecular Weight:288.34

16257-04-8 Synthesis

16257-04-8
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16257-05-9
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Yield:16257-05-9 99%

Reaction Conditions:

with lithium hydroxide monohydrate in tetrahydrofuran;methanol;water at 20; for 2 h;

Steps:

To a solution of Boc-L-Ile-Gly-OMe 20 (2.0 g, 6.6 mmol) in amixture of THF, MeOH, and H2O (1:1:1, 33 mL) was added LiOH.H2O (0.6 g, 14.3 mmol) at roomtemperature. After stirring for 2 h, the reaction mixture was quenched with 1N HCl and extractedwith EtOAc. The combined organic layer was dried over MgSO4 and concentrated in vacuo to afford1.9 g (99%) of Boc-L-Ile-Gly-OH 22 as white solid. The free acid 22 was used in the next step withoutfurther purification.

References:

Lim, Changjin [Molecules,2019,vol. 24,# 19,art. no. 3424]