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ChemicalBook CAS DataBase List BOC-N-ME-ARG(TOS)-OH
108695-16-5

BOC-N-ME-ARG(TOS)-OH synthesis

1synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 10.5 g / NaBH3CN, 1 N aq. HCl / methanol / 18 h / Ambient temperature
2: 95percent aq. HCOOH / 0.75 h / Heating
3: 2.5 g / H2, aq. HCl / 5percent Pd/C / acetic acid / 6 h
4: 1.37 g / NaOH / H2O; 2-methyl-butan-2-ol / 18 h

References:

Ali;Bennett;Calvo;Elliott;Hwang;Ku;Lago;Nichols;Romoff;Shah;Vasko;Wong;Yellin;Yuan;Samanen [Journal of Medicinal Chemistry,1994,vol. 37,# 6,p. 769 - 780]

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