ChemicalBook CAS DataBase List BOC-PHE-OBZL

BOC-PHE-OBZL synthesis

12synthesis methods

Product Name:BOC-PHE-OBZL
CAS Number:66617-58-1
Molecular formula:C21H25NO4
Molecular Weight:355.43

13734-34-4
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100-39-0
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66617-58-1
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Yield:66617-58-1 99%

Reaction Conditions:

with potassium carbonate in acetone;Heating / reflux;

Steps:

1.19(i)

Synthesis of Compound 19; To Boc-(L)-Phe-OH (265 mg, 1.00 mmol) and potassium carbonate (691 mg, 5.0 mmol) in acetone (30 ml) was added benzyl bromide (0.24 ml, 2.0 mmol). The resulting solution was heated at reflux overnight before being cooled, filtered and evaporated to dryness. The resultant residue was subjected to flash column chromatography over silica, eluting with 5% ethyl acetate/hexane to first remove benzyl bromide, then with DCM to yield the product 19(i) as a white solid (351 mg, 99%).¹H NMR (500 MHz, CDCl₃) δ 1.46, s, 9H; 3.12, m, 2H; 4.68, m, IH; 5.15, ABq, J = 12.3 Hz, IH; 5.16, m, NH; 5.19, ABq, / = 12.3 Hz, IH; 7.09, m, 2H; 7.25, m, 3H; 7.32, m, 2H; 7.36, m, 2H. MS (ES +ve) m/z 401.1 (40%) [M+HCOOH]⁺; 378.1 (20) [M+Na]⁺; 356.1 (25) [M+H]⁺; 300.0 (60) [M+H-C+Hsf; 256.0 (100) [M+H-BOC]^"1".

References:

WO2006/74501,2006,A1 Location in patent:Page/Page column 79

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100-51-6 Synthesis