ChemicalBook CAS DataBase List BOC-PRO-GLY-OH

BOC-PRO-GLY-OH synthesis

9synthesis methods

Product Name:BOC-PRO-GLY-OH
CAS Number:51785-82-1
Molecular formula:C12H20N2O5
Molecular Weight:272.3

Glycine, 1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl-, ethyl ester

57294-31-2
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51785-82-1
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Yield:51785-82-1 96%

Reaction Conditions:

with water;sodium hydroxide in tetrahydrofuran at 20;

Steps:

1.3

The compound (3) (1 2 g, 40 mmol) was mixed with tetrahydrofuran. Sodium hydroxide (6.40 g, 1 60 mmol) aqueous solution was added to the mixture solution. The resulting mixture was agitated at room temperature overnight and concentrated. 1 N HCI was added to adjust the pH to 1 .0. The aqueous layer was extracted with ethyl acetate three times. The whole organic layer was dried with anhydrous magnesium sulfate and concentrated to obtain the compound (4) (yield 96%) as white solid. LC-MS (ESI) : calcd for C12H20N2O5 272.1 , found m/z 273.1 (M + H⁺).

References:

WO2017/8033,2017,A1 Location in patent:Page/Page column 55-56