BOC-(RS)-2-AMINO-4-BENZYLOXYBUTANOIC ACID synthesis
- Product Name:BOC-(RS)-2-AMINO-4-BENZYLOXYBUTANOIC ACID
- CAS Number:876617-13-9
- Molecular formula:C16H23NO5
- Molecular Weight:309.36
38308-92-8
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Yield:876617-13-9 89.12%
Reaction Conditions:
with triethylamine in acetone at 55; for 6 h;
Steps:
3 Example 3 Synthesis of intermediate 2 (N-tert-butoxycarbonylhomoserine benzyl ester)
Mix Intermediate 1 (73.08mmol, 16.02g) and triethylamine (146.mmol, 20.00mL) in 200mL of acetone. Add benzyl bromide (87.70mmol, 10.00mL) dropwise under reflux conditions at 55°C. After the end, react for 6h. Rotate the reaction solution to dryness, add 50mL of water, extract 5 times with ethyl acetate (100mL), concentrate the organic layer, wash 2 times with 5% citric acid aqueous solution (50mL), wash once with saturated sodium chloride solution (50ml), anhydrous Dry with sodium sulfate. The organic layer was concentrated and separated by column chromatography (petroleum ether: ethyl acetate=4:1) to obtain Intermediate 2, a white solid, no fluorescence, and ninhydrin color development, to obtain 19.66 g of the product, with a yield of 89.12%.
References:
CN112457218,2021,A Location in patent:Paragraph 0075-0077
24424-99-5
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876617-13-9
11 suppliers
$212.00/1g