Butanoic acid, 2-(aminomethyl)- synthesis

6synthesis methods

Product Name:Butanoic acid, 2-(aminomethyl)-
CAS Number:4385-92-6
Molecular formula:C5H11NO2
Molecular Weight:117.15

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Yield:-

Reaction Conditions:

with hydrogenchloride;water at 100; for 16 h;

Steps:

3 Step 3 - (±)-2-(Aminomethyl)butanoic acid (Intermediate BP)

Step 3 - (±)-2-(Aminomethyl)butanoic acid (Intermediate BP) (0696) [00425] To a solution of (±)-ethyl 2-(aminomethyl)butanoate (500 mg, 3.44 mmol) in water (1.00 mL) was added concentrated hydrochloric acid (12 M, 1.00 mL) and the reaction mixture was stirred at 100 °C for 16 hrs. On completion, the reaction mixture was filtrated and the filtrate was concentrated in vacuo to give the title compound (700 mg, crude) as a black/brown oil used without further purification. LCMS: (ES⁺) m/z (M+H)⁺ = 118.0, tR= 0.326.

References:

WO2017/156181,2017,A1 Location in patent:Paragraph 00425

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