![](/CAS/GIF/612541-12-5.gif)
BUTTPARK 87\03-67 synthesis
- Product Name:BUTTPARK 87\03-67
- CAS Number:612541-12-5
- Molecular formula:C8H6ClF3O3S
- Molecular Weight:274.64
![4-(Trifluoromethyl)anisole](/CAS/GIF/402-52-8.gif)
402-52-8
130 suppliers
$14.00/1g
![BUTTPARK 87\03-67](/CAS/GIF/612541-12-5.gif)
612541-12-5
14 suppliers
$531.00/250mg
Yield:612541-12-5 11%
Reaction Conditions:
with chlorosulfonic acid at 0 - 20;
Steps:
I-2.1 2-Methoxy-5-trifluoromethylbenzenesulfonyl chloride
To chloro sulfuric acid (15 mL) was added l-methoxy-4-trifluoromethyl- benzene (3.0 g, 17 mmol) portionwise at 0°C. The mixture was stirred at room temperature overnight. The mixture was poured into ice. the aqueous layer was extracted with EtOAc (50 mL x3). The extracts were dried over Na2S04 and the solution was filtered through a pad of silica gel, dried in vacuum to afford 500 mg (yield: 11%) of 2-methoxy-5-trifluoromethyl- benzenesulfonyl chloride as white solid. [00183] 1H NMR (DMSO-d6): δ = 7.90 (1H, d), 7.67 (1H, dd), 7.18 (1H, d), 3.84 (3H, s).
References:
WO2013/126608,2013,A1 Location in patent:Paragraph 00182-00183