C-((S)-1-Benzyl-pyrrolidin-2-yl)-MethylaMine synthesis

10synthesis methods

Product Name:C-((S)-1-Benzyl-pyrrolidin-2-yl)-MethylaMine
CAS Number:96948-23-1
Molecular formula:C12H18N2
Molecular Weight:190.28

60169-70-2
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C-((S)-1-Benzyl-pyrrolidin-2-yl)-MethylaMine

96948-23-1
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Yield:96948-23-1 59%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 0;Inert atmosphere;

Steps:

44.2 Intermediate STEP 2:

To a solution of (2S)-1-benzylpyrrolidine-2-carboxamide (200mg, 0.98mmol, 1.0eq) in THF was added LiAlhU (2.94mL, 3.0eq), the mixture was stirred at 0°C under N2 overnight. The reaction was quenched with water, dried over sodium sulfate and the filtrate concentrated in vacuo. The residue was purified by column chromatography to give [(2S)-1-benzylpyrrolidin-2- yl]methanamine (110mg, 59%).UPLC-MS (ES+, short acidic): 0.60 min, m/z 191.2 [M+H]+

References:

WO2021/152149,2021,A1 Location in patent:Paragraph 000150