ChemicalBook CAS DataBase List CAINDEXNAME:L-TYROSINE,2-FLUORO-5-HYDROXY-

CAINDEXNAME:L-TYROSINE,2-FLUORO-5-HYDROXY- synthesis

7synthesis methods

Product Name:CAINDEXNAME:L-TYROSINE,2-FLUORO-5-HYDROXY-
CAS Number:75290-51-6
Molecular formula:C9H10FNO4
Molecular Weight:215.18

853759-49-6 Synthesis

N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-L-tyrosine Methyl Ester

853759-49-6
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CAINDEXNAME:L-TYROSINE,2-FLUORO-5-HYDROXY-

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Yield:-

Reaction Conditions:

with hydrogen bromide in water; for 5 h;

Steps:

1.c Synthesis of F-Dopa

Step (c): synthesis of (2S)-2-amino-3-(2-fluoro-4,5-dihydroxy-phenyl)-propionic acid. HBr (10 mL, 48% water solution) is added to the reaction product of step (b). The reaction is heated in an oil bath for 5 hours. LC/MS analysis indicates complete consumption of the starting material. The reaction mixture is concentrated to dryness and the structural data indicates that the product is F-Dopa. MS: Calculated for C₉H₁₀FNO₄: 215.06; found: 216 (M+H), 238 (M+H), 214 (M-H). ¹H NMR (300 MHz, C₂D₆SO) δ: 2.87-2.98 (2H, m), 3.95 (1H, s), 6.52-6.62 (2H, m), 8.23 (3H, s), 8.84 (1H, s), 9.35 (1H, s), 13.74 (1H, s).

References:

US2005/137421,2005,A1 Location in patent:Page/Page column 5

L-Tyrosine, 2-fluoro-5-methoxy-O-methyl-

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75290-51-6
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References

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References

59-92-7 Synthesis

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References

L-Tyrosine, 3-methoxy-O-methyl-N-(trifluoroacetyl)-, ethyl ester (9CI)

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References