CALIX(8)ARENE synthesis

Yield:82452-93-5 96%

Reaction Conditions:

with aluminum (III) chloride;phenol in toluene for 1 h;Inert atmosphere;

Steps:

1-3 Example 1
Take 4 g of p-tert-butylcalirene aromatics, Phenol 2.72g, Anhydrous aluminum chloride 5.22g, Placed in a 250 mL two-neck round bottom flask, And poured 60 mL of toluene. Stir on a magnetic stirrer, Under the protection of N2, Reaction 1h. The color of the mixture changed from a colorless turbid liquid to an orange turbid liquid. Pour the mixture into 100 mL of 0.2 mol•L-1 hydrochloric acid solution. The upper white gel was separated by a separating funnel. Placed in a round bottom flask, Rotary evaporation, Obtained a white solid, Then use acetone, Methanol, Chloroform, Wash with ether, The filter cake is dried, An off-white butterane aromatic hydrocarbon was obtained as an off-white solid. The yield was 96% and the product purity was greater than 98%.

References:

Hunan Institute of Science and Technology;Yang Xin;Liang Enxiang;Yi Jianmin CN109575070, 2019, A Location in patent:Paragraph 0010; 0017; 0020; 0022

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