CAY10648 synthesis

Yield:916048-02-7 225 mg

Reaction Conditions:

Stage #1: 5-chloro-2'H-spiro[indole-3,3'-pyrrolidine]-2,2'(1H)-dionewith potassium tert-butylate in N,N-dimethyl-formamide at 20; for 0.166667 h;
Stage #2: bromoacetic acid tert-butyl ester in N,N-dimethyl-formamide at 20; for 4 h;Further stages.;

References:

Crosignani, Stefano;Page, Patrick;Missotten, Marc;Colovray, Véronique;Cleva, Christophe;Arrighi, Jean-Fran?ois;Atherall, John;Macritchie, Jackie;Martin, Thierry;Humbert, Yves;Gaudet, Marilène;Pupowicz, Doris;Maio, Maurizio;Pittet, Pierre-André;Golzio, Lucia;Giachetti, Claudio;Rocha, Cynthia;Bernardinelli, Gérald;Filinchuk, Yaroslav;Scheer, Alexander;Schwarz, Matthias K.;Chollet, André [Journal of Medicinal Chemistry,2008,vol. 51,# 7,p. 2227 - 2243]