![](/CAS/20180906/GIF/916048-02-7.gif)
CAY10648 synthesis
- Product Name:CAY10648
- CAS Number:916048-02-7
- Molecular formula:C17H19ClN2O4
- Molecular Weight:350.8
![Spiro[3H-indole-3,3'-pyrrolidine]-2,2'(1H)-dione, 5-chloro-](/CAS/20210305/GIF/916048-01-6.gif)
916048-01-6
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![tert-Butyl bromoacetate](/CAS/GIF/5292-43-3.gif)
5292-43-3
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$10.00/5g
![CAY10648](/CAS/20180906/GIF/916048-02-7.gif)
916048-02-7
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$71.00/1mg
Yield:916048-02-7 225 mg
Reaction Conditions:
Stage #1: 5-chloro-2'H-spiro[indole-3,3'-pyrrolidine]-2,2'(1H)-dionewith potassium tert-butylate in N,N-dimethyl-formamide at 20; for 0.166667 h;
Stage #2: bromoacetic acid tert-butyl ester in N,N-dimethyl-formamide at 20; for 4 h;Further stages.;
References:
Crosignani, Stefano;Page, Patrick;Missotten, Marc;Colovray, Véronique;Cleva, Christophe;Arrighi, Jean-Fran?ois;Atherall, John;Macritchie, Jackie;Martin, Thierry;Humbert, Yves;Gaudet, Marilène;Pupowicz, Doris;Maio, Maurizio;Pittet, Pierre-André;Golzio, Lucia;Giachetti, Claudio;Rocha, Cynthia;Bernardinelli, Gérald;Filinchuk, Yaroslav;Scheer, Alexander;Schwarz, Matthias K.;Chollet, André [Journal of Medicinal Chemistry,2008,vol. 51,# 7,p. 2227 - 2243]