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144249-05-8

Cbz-Leu-Abu-OH synthesis

5synthesis methods
Butanoic acid, 2-[[(2S)-4-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-, methyl ester

144249-03-6
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Cbz-Leu-Abu-OH

144249-05-8
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Yield:144249-05-8 89%

Reaction Conditions:

with sodium hydroxide in methanol;water;

References:

Ovat, Asli;Li, Zhao Zhao;Hampton, Christina Y.;Asress, Seneshaw A.;Fernández, Facundo M.;Glass, Jonathan D.;Powers, James C. [Journal of Medicinal Chemistry,2010,vol. 53,# 17,p. 6326 - 6336] Location in patent:supporting information; experimental part