ChemicalBook CAS DataBase List CBZ-N-AMIDO-PEG4-ALCOHOL

CBZ-N-AMIDO-PEG4-ALCOHOL synthesis

7synthesis methods

Product Name:CBZ-N-AMIDO-PEG4-ALCOHOL
CAS Number:206265-31-8
Molecular formula:C16H25NO6
Molecular Weight:327.37

86770-74-3 Synthesis

86770-74-3
178 suppliers
$16.00/100mg

501-53-1
394 suppliers
$10.00/1g

206265-31-8
16 suppliers
$220.00/0.5g

Yield:206265-31-8 85%

Reaction Conditions:

with Sodium hydrogenocarbonate in lithium hydroxide monohydrate;ethyl acetate at 20;

Steps:

7

To a mixture of commercially available amino alcohol 6 (50.0 g, 258.75 mmol, 1eq) in EtOAc (250 mL) 250 mL H2O was added NaHCO3 (30.4 g, 362.25 mmol, 1.4 eq), followed by addition of CbzCl (36.8 mL, 258.75 mmol, 1 eq) at rt. The mixture was stirred at rt overnight. Work-up: Organic layer was separated, aqueous phase was extracted with EtOAc (80 mlX2), and dried over MgSO4. The residue was purified by flash chromatography using 30% to 50% EtOAc/Hept to give compound 7 (72 g, 85% yield) as a syrup.

References:

WO2022/76922,2022,A1 Location in patent:Page/Page column 169-171

86770-67-4
160 suppliers
$34.00/250mg

206265-31-8
16 suppliers
$220.00/0.5g

References

77544-60-6
103 suppliers
$69.70/1g

206265-31-8
16 suppliers
$220.00/0.5g

References

112-60-7
347 suppliers
$7.00/25g

206265-31-8
16 suppliers
$220.00/0.5g

References

1H-Isoindole-1,3(2H)-dione, 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-

90331-86-5
3 suppliers
inquiry

206265-31-8
16 suppliers
$220.00/0.5g

References