CHEMBRDG-BB 4005901 synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 0.42 h / -85 °C
1.2: 0.25 h / -85 °C
2.1: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 18 h / 80 °C / 22502.3 Torr / Autoclave

References:

Subota, Andrii I.;Lutsenko, Anton O.;Vashchenko, Bohdan V.;Volochnyuk, Dmitriy M.;Levchenko, Vitalina;Dmytriv, Yurii V.;Rusanov, Eduard B.;Gorlova, Alina O.;Ryabukhin, Sergey V.;Grygorenko, Oleksandr O. [European Journal of Organic Chemistry,2019,vol. 2019,# 22,p. 3636 - 3648]