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CHEMBRDG-BB 4010847 synthesis

3synthesis methods
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Yield:751468-47-0 88%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 0.333333 h;

Steps:

General procedure C for Boc deprotection of piperazine analogs

General procedure: To a solution of N-Boc piperazine analog (0.44 mmol, 1 eq.) in DCM (3 mL) was added TFA (3 mL). The mixture was stirred at rt for 20 min, then quenched with a NaH CO3 saturated solution. The aqueous phase was extracted with DCM. The organic layer was dried over anhydrous MgSO4 , concentrated under reduced pressure to afford the desired compound without further purification.

References:

WO2022/195102,2022,A1 Location in patent:Page/Page column 59; 70-71