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CHEMBRDG-BB 4011184 synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 100 percent / CH2Cl2
2: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2
3: NaCNBH3; CF3CH2OH; 3A sieves
4: 100 percent / CF3COOH / CH2Cl2

References:

Ting, Pauline C;Lee, Joe F;Anthes, John C;Shih, Neng-Yang;Piwinski, John J [Bioorganic and Medicinal Chemistry Letters,2001,vol. 11,# 4,p. 491 - 494]