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ChemicalBook CAS DataBase List CHEMBRDG-BB 4014416
915924-79-7

CHEMBRDG-BB 4014416 synthesis

4synthesis methods
38267-96-8 Synthesis
6-Bromo-4-chloroquinazoline

38267-96-8
178 suppliers
$8.00/1g

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Yield:915924-79-7 84%

Reaction Conditions:

at 20; for 2 h;

Steps:

8.A

6-Bromo-4-chloroquinazoline (1.00 g, 4.11 mmol) was treated with 0.5M NaOMe (82.1 mL, 41.1 mmol) at room temperature for 2 hours. The reaction mixture was concentrated, and the crude solids were washed with water and dried in vacuo to give 6- bromo-4-methoxyquinazoline (0.83 g, 84% yield) as a solid. LC/MS: m/z 239.0, 241.0 [M+l].

References:

WO2012/118492,2012,A1 Location in patent:Page/Page column 78

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