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CHEMBRDG-BB 4016108 synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: zinc; acetic acid / water; toluene / 3 h / 45 °C
1.2: 0 °C
2.1: pyridine; hydroxylamine hydrochloride / ethanol / 25 °C
3.1: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 25 °C / Sealed tube; Inert atmosphere

References:

Chen, Hong-Lei;Wei, Dian;Zhang, Jian-Wu;Li, Cheng-Lin;Yu, Wei;Han, Bing [Organic Letters,2018,vol. 20,# 10,p. 2906 - 2910]

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