CHEMBRDG-BB 5904367 synthesis

Yield:1191455-39-6 88%

Reaction Conditions:

with sodium tetrahydroborate in ethanol at 25; for 2.5 h;

Steps:

I

A solution of 1-(5-methyl-3-nitro-pyrazol-1-yl)-propan-2-one (500 mg, 2.9 mmol) in ethanol (15 ml) was treated with sodium borohydride (111 mg, 0.29 mmol). The reaction was stirred at 25° C. for 2.5 h. At this time, the reaction was poured onto water and was extracted into ethyl acetate. The organics were concentrated in vacuo to afford 1-(5-methyl-3-nitro-pyrazol-1-yl)-propan-2-ol (440 mg, 88%) which was used without further purification; ES⁺-HRMS m/e calcd for C₇H₁₁N₃O₃ [M+H⁺] 186.0873, found 186.0873.

References:

US2009/264434,2009,A1 Location in patent:Page/Page column 73