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CHEMBRDG-BB 9071188 synthesis

4synthesis methods
14371-10-9 Synthesis
trans-Cinnamaldehyde

14371-10-9
315 suppliers
$6.00/25g

109-73-9 Synthesis
Butylamine

109-73-9
439 suppliers
$9.00/1g

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Yield:155687-67-5 86%

Reaction Conditions:

Stage #1: (E)-3-phenylpropenal;N-butylaminewith magnesium sulfate in methanol at 20; for 18 h;
Stage #2: with sodium tetrahydroborate in methanol at 0 - 20; for 1 h;

References:

Hemelaere, Rémy;Desroches, Justine;Paquin, Jean-Fran?ois [Organic Letters,2015,vol. 17,# 7,p. 1770 - 1773] Location in patent:supporting information