CHLOROBENZENE-4-D1 synthesis

9synthesis methods

Product Name:CHLOROBENZENE-4-D1
CAS Number:13122-34-4
Molecular formula:C6H4ClD
Molecular Weight:113.56

106-39-8 Synthesis

106-39-8
444 suppliers
$14.00/5g

13122-34-4
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$76.00/25mg

Yield:13122-34-4 88%

Reaction Conditions:

with neopentyl chloride;sodium in hexane;paraffin oil at 0; for 0.5 h;

Steps:

6.5 Experiment Number 5

0.25 mmol (1.0 molar equivalent) of 1-bromo-4-chlorobenzene was added to neopentyl sodium synthesized in the same manner as in Experiment Number 1, and the mixture was reacted in hexane at 0° C. for 30 minutes to synthesize 4-chlorophenyl sodium. A product was evaluated by trapping the product with 0.3 mmol (1.2 molar equivalents) of chlorodimethylphenylsilane, performing ¹H NMR measurement and calculating a yield, in the same manner as in Examination Example 2. The results are shown in FIG. 7. As shown in FIG. 7, the yield of 4-chlorophenyl sodium was 88%.

References:

US2021/388004,2021,A1 Location in patent:Paragraph 0027; 0101; 0106