ChemicalBook CAS DataBase List chlorocyclopropane

chlorocyclopropane synthesis

15synthesis methods

Product Name:chlorocyclopropane
CAS Number:7393-45-5
Molecular formula:C3H5Cl
Molecular Weight:76.52

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Yield: 72.8%

Reaction Conditions:

with n-butyllithium in tetrahydrofuran;hexane at -25 - -20; for 4 h;

Steps:

2.1.2 1.2 Chlorocyclopropane
Add 1,1-dichlorocyclopropane and tetrahydrofuran to a three-necked flask, stir evenly, and lower the temperature to -25°C.Add the hexane solution of n-butyllithium dropwise through the dropping funnel, control the reaction temperature to be lower than -20°C, after dropping, react at -20°C for 4 h.Use gas chromatography to track the progress of the reaction. After the reaction is completed, the temperature is gradually increased to 0°C.Add 36 g of water dropwise through the dropping funnel to control the reaction temperature to be lower than 5°C. After the dropping is completed, stir for 1 hour. Let stand for layering, separate the organic layer, carry out rectification, and collect the 4042 fraction,Obtained 26 g of chlorocyclopropane, gas chromatography purity: 97.4%, yield: 72.8%.

References:

CN112573992, 2021, A Location in patent:Paragraph 0016

75-19-4 Synthesis