Chloromethyl palmitate synthesis
- Product Name:Chloromethyl palmitate
- CAS Number:61413-69-2
- Molecular formula:C17H33ClO2
- Molecular Weight:304.9
49715-04-0
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Yield:61413-69-2 85%
Reaction Conditions:
with sodium hydrogencarbonate;tetrabutylammonium sulfate in dichloromethane;water at 0 - 20;
Steps:
1.1 Step-1 Synthesis of Chloromethyl Palmitate (2b)
Palmitic acid (0.3 g, 1.17 mmol) was dissolved in 5 ml dichloromethane (DCM) followed by addition of sodium bicarbonate (0.4 g, 4.68 mmol), 5 ml water and tetrabutylammonium sulfate (0.135 ml, 0.117 mmol). The resultant solution was stirred vigorously at 0° C. After 10 min, chloromethyl chlorosulfate (0.14 ml, 1.4 mmol) in DCM was added into the reaction mixture and the resultant solution was allowed to stir vigorously until room temperature was achieved. The organic layer was extracted with DCM, washed with brine and finally dried over sodium sulfate to obtain pure chloromethyl palmitate (0.3 g, 85% yield).
References:
US2014/364595,2014,A1 Location in patent:Paragraph 0414
