Chlorosulfonamide synthesis
- Product Name:Chlorosulfonamide
- CAS Number:7778-42-9
- Molecular formula:ClH2NO2S
- Molecular Weight:115.54
64-18-6
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7778-42-9
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Yield:7778-42-9 100%
Reaction Conditions:
in toluene at 23; for 10 h;Inert atmosphere;
Steps:
1.e.1 E.1 : Sulfamoyl chloride
Caution: this experiment must be performed under a fume hood since a strong release of carbon dioxide and carbon monoxide occurs. Chlorosulfonyl isocyanate (17.4 mL, 200 mmol) was introduced into a 250 mL round bottom flask. Under an inert atmosphere, formic acid (7.54 mL, 200 mmol) was slowly added followed by toluene (60 mL). The resulting mixture was stirred 10 hours at 23°C. The solvent was removed to dryness under reduced pressure to afford the final product as a crystalline solid (23 g, quantitative yield). The compound was used in the next steps without further purification.
References:
BEAUFOUR IPSEN TIANJIN PHARMACEUTICAL CO., LTD;AUVIN, Serge;LAVERGNE, Olivier;CHAO, Qi;CHEN, Yufeng WO2015/100609, 2015, A1 Location in patent:Page/Page column 30; 31
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7732-18-5
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7778-42-9
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