Ciprofloxacin synthesis
- Product Name:Ciprofloxacin
- CAS Number:85721-33-1
- Molecular formula:C17H18FN3O3
- Molecular Weight:331.34
110-85-0
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93107-30-3
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85721-33-1
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Yield:85721-33-1 960 mg
Reaction Conditions:
in (methylsulfinyl)methane;Heating;
Steps:
2 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-l-yl)-l,4-dihydroquinoIine-3-carboxylic acid (1)
To a solution of 7 (3.77 mmoles) in DMSO (30 mL) in a round bottom flask was added the piperazine ( 15 mmoles) and the mixture was heated to 90 °C. The reaction was monitored by HPLC. Upon complete consumption of the starting material, the reaction mixture was cooled to room temperature. 4 N HCl was added to the mixture to adjust the pH to 7. Ciprofloxacin (1) was allowed to gradually precipitate in a 4 °C fridge. The solid was filtered, washed three times with water and three times with acetone and dried, affording 960 mg yellow solid.
References:
WO2018/231747,2018,A2 Location in patent:Page/Page column 19; 33; 36-37
93107-08-5
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85721-33-1
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93594-48-0
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85721-33-1
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110-85-0
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$5.00/5G
86393-33-1
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85721-33-1
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