Clomipramine synthesis
- Product Name:Clomipramine
- CAS Number:303-49-1
- Molecular formula:C19H23ClN2
- Molecular Weight:314.85
![5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine](/CAS/GIF/25961-11-9.gif)
25961-11-9
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303-49-1
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$189.52/250mg
Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: potassium hydroxide; triethyl borane / tetrahydrofuran / 24 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
3.1: sodium hydride / tetrahydrofuran / 2 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
3.2: 22 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
References:
Li, Jinshan;Wang, Jiali;Yang, Jianguo;Yao, Wubing;Zhong, Aiguo [Organic Letters,2020,vol. 22,# 20,p. 8086 - 8090]
![3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine](/CAS/GIF/32943-25-2.gif)
32943-25-2
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53929-74-1
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303-49-1
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14171-67-6
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$80.00/1mg
303-49-1
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106-39-8
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$14.00/5g
303-49-1
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615-36-1
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$10.00/5g
303-49-1
116 suppliers
$189.52/250mg