ChemicalBook CAS DataBase List CORTEX ALDEHYDE 50 BENZYL ALCOHOL

CORTEX ALDEHYDE 50 BENZYL ALCOHOL synthesis

14synthesis methods

Product Name:CORTEX ALDEHYDE 50 BENZYL ALCOHOL
CAS Number:2120-70-9
Molecular formula:C8H8O2
Molecular Weight:136.15

From phenol in weak aqueous alkali with monochloroacetaldehyde dimethyl acetal to yield the acetal which is then hydrolysed.

538-43-2
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2120-70-9
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$76.00/100mg

Yield: 100%

Reaction Conditions:

with sodium periodate in dichloromethane for 0.166667 h;

Steps:

68
Sodium periodate (0.65 M in water, 20 mL) was added to a vigourously stirred suspension of silica gel (20 g) in dichloromethane (160 mL), followed by a solution of 3-phenoxy-l,2- propanediol (1.68 g, 10.0 mmol) in dichloromethane (20 mL). After stirring for 10 min the mixture was filtered and the filtrate was concentrated to give the subtitle compound (1.36 g,100 %).¹H-NMR (400 MHz, CDCl₃): δ 9.89 (s, 1H9, 7.33 (m, 2H), 7.04 (m, IH), 6.92 (m, 2H), 4.59(S, 2H).

References:

ASTRAZENECA AB;BAYER SCHERING PHARMA AKTIENGESELLSCHAFT WO2008/76048, 2008, A1 Location in patent:Example 68