Crystal violet lactone synthesis
- Product Name:Crystal violet lactone
- CAS Number:1552-42-7
- Molecular formula:C26H29N3O2
- Molecular Weight:415.53
![2-[bis[4-(dimethylamino)phenyl]methyl]-5-(dimethylamino)benzoic acid](/CAS/GIF/1255-69-2.gif)
1255-69-2
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1552-42-7
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Yield:1552-42-7 95.4%
Reaction Conditions:
with hydrogenchloride;sodium hydroxide in water
Steps:
1 EXAMPLE 1
EXAMPLE 1 To a 500 ml reaction vessel, 21.5 g of 2-[4,4'-bis(dimethylamino) benzhydryl]-5-dimethylaminobenzoic acid having a purity of 97.0% was charged and 250 g of water was added. To the dispersion thus obtained, 21.5 g of activated carbon; SHIRASAGI-C (manufactured by Takeda Chemical Ind. Co.) and 2.0 g of a 49% aqueous NaOH solution were added and stirred at 90 to 95° C. Through the reaction system thus obtained air was blown for 9 hours at a rate of 400 ml/min. After finishing the reaction, the reaction mass was filtered and the obtained cake was slurried in water, and completely dissolved by adding 19.5 g of a 36% aqueous HCl solution. Thereafter, the activated carbon was filtered. The filtrate was neutralized to pH7.0 with a 49% aqueous NaOH solution. The precipitated crystals were filtered, washed and dried to obtain 20.1 g of 3,3-bis(4-dimethylaminophenyl)-6-dimethylaminophthalide. The yield was 95.4%. Formation of by-product in the reaction was 1.5%. Selectivity of reaction was 98.4%.
References:
Mitsui Chemicals, Inc.;Yamamoto Chemicals US5973168, 1999, A
![3,3-bis[4-(dimethylamino)phenyl]phthalide](/CAS/GIF/5339-80-0.gif)
5339-80-0
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1552-42-7
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![3,3-bis[4-(dimethylamino)phenyl]-6-nitro-2-benzofuran-1-one](/CAS/20180720/GIF/29199-08-4.gif)
29199-08-4
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1552-42-7
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100-10-7
601 suppliers
$5.00/1g
1552-42-7
267 suppliers
$8.00/5g