ChemicalBook CAS DataBase List CYCLO(-ALA-GLU)

CYCLO(-ALA-GLU) synthesis

4synthesis methods

Product Name:CYCLO(-ALA-GLU)
CAS Number:16364-36-6
Molecular formula:C8H12N2O4
Molecular Weight:200.19

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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Yield: 94%

Reaction Conditions:

with hydrogen;palladium in 2,2,2-trifluoroethanol for 48 h;

Steps:

1.d
Cyclo-L-Ala-L-Glu(OBzl) (14.5 g, 0.05 mol) was dissolved in 200 ml of trifluorethanol and then 1.5 g of palladium black was added. Hydrogen was bubbled through the suspension and the mixture was stirred for 48 hours. The completion of the reaction was monitored by TLC. After the reaction was complete, the catalyst was filtered off and the solvent was evaporated in vacuum. The residual peptide was dissolved in 200 ml of distilled water and the impurities were extracted with 3x100 ml of EtOAc. The water phase was combined and evaporated in vacuum. The precipitate was washed with ether and hexane and then dried in air. The yield was 10.2 g (94%). Rf=0.2(CHCl₃:EtOAc:MeOH:AcOH=6:3: l :0.1);Rr0.5(CHCl₃:EtOAc:MeOH:32%Ac OH=6:3: 1 :0.1); HPLC data: retention time 6.7 min.

References:

MANUS PHARMACEUTICALS (CANADA) LTD. WO2008/14613, 2008, A1 Location in patent:Page/Page column 22-23

1676-73-9
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16364-36-6
58 suppliers
$70.00/5 mg

References

1000210-73-0
0 suppliers
inquiry

16364-36-6
58 suppliers
$70.00/5 mg

References

1000210-73-0
0 suppliers
inquiry

16364-36-6
58 suppliers
$70.00/5 mg

References

CYCLO(-ALA-GLU) Related Search:

3-PIPERAZIN-2-YL-PROPIONIC ACID