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ChemicalBook CAS DataBase List CYCLO(-HIS-PHE)

CYCLO(-HIS-PHE) synthesis

5synthesis methods
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Yield:56586-95-9 39%

Reaction Conditions:

Stage #1: N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidinewith triethylamine in N,N-dimethyl-formamide; for 24 h;
Stage #2: with hydrogenchloride in ethyl acetate; for 0.5 h;
Stage #3: N-tert-butoxycarbonyl-L-phenylalanineFurther stages;

References:

Kleinsmann, Alexander J.;Nachtsheim, Boris J. [Chemical Communications,2013,vol. 49,# 71,p. 7818 - 7820] Location in patent:supporting information

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