Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI) synthesis
- Product Name:Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI)
- CAS Number:376348-75-3
- Molecular formula:C7H9ClF2O
- Molecular Weight:182.6
122665-97-8
276 suppliers
$18.00/250mg
376348-75-3
26 suppliers
$90.00/50mg
Yield:376348-75-3 100%
Reaction Conditions:
with dichloro sulfoxide in toluene;Reflux;
Steps:
The preparation of 4,4-difluorocyclohexanecarbonyl chloride (8)
To the solution of 4,4-difluorocyclohexanecarboxylic acid (3 g, 18.3 mmol, 1 Eq.) dissolved in 7.5 ml toluene SOCl2 (6.6 ml, 5 Eq.) was added. The mixture was refluxed and stirred for 2-3 h. TLC showed the acid was consumed up, cooled, concentrated to yield about 2.5 g dryness oil (100% yield).
References:
Zhu, Yijun;Li, Hongyan;Lin, Kuaile;Wang, Bing;Zhou, Weicheng [Synthetic Communications,2019,vol. 49,# 13,p. 1721 - 1728] Location in patent:supporting information
122665-97-8
276 suppliers
$18.00/250mg
7719-09-7
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$15.00/10g
376348-75-3
26 suppliers
$90.00/50mg
178312-47-5
176 suppliers
$8.00/1g
376348-75-3
26 suppliers
$90.00/50mg
17159-79-4
334 suppliers
$5.00/1g
376348-75-3
26 suppliers
$90.00/50mg