![](/CAS/GIF/810659-05-3.gif)
(4,4-difluorocyclohexyl)methanamine synthesis
- Product Name:(4,4-difluorocyclohexyl)methanamine
- CAS Number:810659-05-3
- Molecular formula:C7H13F2N
- Molecular Weight:149.18
![CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO-](/CAS/GIF/922728-21-0.gif)
922728-21-0
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![(4,4-difluorocyclohexyl)methanamine](/CAS/GIF/810659-05-3.gif)
810659-05-3
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Yield: 87%
Reaction Conditions:
with hydrogen;Raney 2800 nickel in ethanol;water under 2585.81 Torr;Product distribution / selectivity;
Steps:
[(4,4-Difluorocyclohexyl)methyl]amineRaney 2800 nickel, slurry in water, active catalyst (6 mL) was added to a solution of 4,4-difluorocyclohexanecarbonitrile (18.2 g, 125 mmol) in EtOH (300 mL). The reaction mixture was shaken overnight in a Parr hydrogenation apparatus under a 50 PSI atmosphere of hygrogen. The reaction mixture was filtered over a celite pad and the solvent was concentrated to provide the title compound as a colorless liquid. Yield 16 g (87%). 1H NMR (400 MHz, CHLOROFORM-D): δ 1.17 - 1.46 (m, 3 H), 1.52 - 1.94 (m, 2 H), 2.03 - 2.32 (m, 2 H), 2.57 - 2.70 (m, 2 H).
References:
ASTRAZENECA AB WO2007/13848, 2007, A1 Location in patent:Page/Page column 10
![Cyclohexanecarboxamide, 4,4-difluoro-](/CAS/GIF/927209-98-1.gif)
927209-98-1
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![(4,4-difluorocyclohexyl)methanamine](/CAS/GIF/810659-05-3.gif)
810659-05-3
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![(4,4-DifluorocyclohexylMethyl)carbaMic acid tert-butyl ester](/CAS/20150408/GIF/809273-64-1.gif)
809273-64-1
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810659-05-3
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![8,8-difluoro-1,4-dioxaspiro[4.5]decane](/CAS/20150408/GIF/176251-49-3.gif)
176251-49-3
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![Diethyl ether](/CAS/GIF/60-29-7.gif)
60-29-7
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![4,4-DIFLUOROCYCLOHEXANONE](/CAS/GIF/22515-18-0.gif)
22515-18-0
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$5.00/100mg
![(4,4-difluorocyclohexyl)methanamine](/CAS/GIF/810659-05-3.gif)
810659-05-3
58 suppliers
$45.00/25mg
![4-(Azidomethyl)-1,1-difluorocyclohexane](/CAS/20211123/GIF/1122648-78-5.gif)
1122648-78-5
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![(4,4-difluorocyclohexyl)methanamine](/CAS/GIF/810659-05-3.gif)
810659-05-3
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$45.00/25mg