Cyclohexanesulfonamide(7CI,8CI,9CI) synthesis

6synthesis methods

Product Name:Cyclohexanesulfonamide(7CI,8CI,9CI)
CAS Number:2438-38-2
Molecular formula:C6H13NO2S
Molecular Weight:163.24

Cyclohexanamine, N-(2-methylpropylidene)-, [N(E)]-

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2438-38-2
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Yield:2438-38-2 97.5%

Reaction Conditions:

with sulfur trioxide in 1,1-dichloroethane;water;

Steps:

5 EXAMPLE 5

EXAMPLE 5 45.4 parts of isobutylidene-cyclohexylamine are added in the course of 30 minutes to 19.25 parts of SO₃ in 100 parts of dichloroethane at -10° C. The mixture is then stirred for 1 hour at 0° C, after which it is treated with 4.5 parts of water in the course of 5 minutes at 0° C. The resulting suspension is filtered after stirring for 1.5 hours, and the mother liquor is evaporated under 40 mbar pressure. The residue is combined with the material on the filter, and dried. 42.0 parts of cyclohexylamidosulfonic acid (97.5% of theory) of melting point 169° C are obtained.

References:

US4097521,1978,A