Cyclohexanone, 3-(3-chlorophenyl)-, (3R)- synthesis
1synthesis methods
- Product Name:Cyclohexanone, 3-(3-chlorophenyl)-, (3R)-
- CAS Number:479639-20-8
- Molecular formula:C12H13ClO
- Molecular Weight:208.68
Yield:479639-20-8 98%
Reaction Conditions:
with potassium fluoride;chlorobis(ethylene)rhodium(I) dimer;(R)-1-(tert-butylsulfinyl)-2-(prop-1-en-2-yl)benzene in methanol;dichloromethane;water at 40; for 3 h;Inert atmosphere;optical yield given as %ee;enantioselective reaction;
References:
Chen, Guihua;Gui, Jiangyang;Li, Liangchun;Liao, Jian [Angewandte Chemie - International Edition,2011,vol. 50,# 33,p. 7681 - 7685] Location in patent:supporting information; experimental part