Cyclopenta[c]pyrrol-1(2H)-one, hexahydro- synthesis
- Product Name:Cyclopenta[c]pyrrol-1(2H)-one, hexahydro-
- CAS Number:56593-76-1
- Molecular formula:C7H11NO
- Molecular Weight:125.17
252662-66-1
0 suppliers
inquiry
56593-76-1
3 suppliers
inquiry
Yield:56593-76-1 65%
Reaction Conditions:
with hydrogen;nickel;sodium hydroxide in water;isopropyl alcohol at 20; under 15001.5 Torr; for 16 h;
Steps:
3 Example 3: Preparation of a compound of formula III
The compound of formula II (0.5 g, 2.51 mmol) was charged into a high pressure hydrogenation reactor,Isopropyl alcohol (10 mL), Raney nickel(A-7063) (0.5g) and 10% aqueous NaOH (4mL),After replacing high-purity H2 three times, it was charged with 2.0 MPa H2, and the reaction was stirred at room temperature for 16 hours.H2 is removed from the fume hood, and the TLC test is complete.Diatomaceous earth filtered out of Raney nickel, ethyl acetate (10 mL X 3)Wash the filter residue three times,The filtrate was combined and concentrated under reduced pressure.Obtaining a compound of formula III as a pale yellow solid(0.21 g, yield 65%).
References:
CN109206357,2019,A Location in patent:Paragraph 0072; 0073; 0074; 0075; 0076
25662-28-6
122 suppliers
$8.00/1g
56593-76-1
3 suppliers
inquiry
5763-44-0
184 suppliers
$8.00/5g
56593-76-1
3 suppliers
inquiry
611-10-9
398 suppliers
$10.00/5g
56593-76-1
3 suppliers
inquiry